Glycogenolysis: Definition and Overview

What is glycogenolysis?

Glycogenolysis refers to the breakdown of glycogen[1], the stored form of energy found in muscle and liver tissue, into glucose, which the body can readily use. It plays an important role in the regulation of glucose in the blood. For example, as part of the body’s “fight or flight” reaction to stressors, the adrenal glands release the hormone epinephrine, which stimulates glycogenolysis to provide immediate energy for muscle activity.

Where does glycogenolysis occur?

Glycogenolysis is also important for blood glucose regulation in people with diabetes. When blood glucose levels drop too low, the release of epinephrine and another hormone, glucagon, stimulates glycogenolysis to restore blood glucose levels to normal. People with type 1 diabetes[2] may eventually lose the ability to secrete glucagon and epinephrine, setting the stage for severe hypoglycemia[3]. The symptoms of mild-to-moderate hypoglycemia typically include shaking, sweating, hunger, and headache, alerting the person for the need to consume carbohydrate. However, people suffering from severe hypoglycemia may be unable to eat or drink, may have seizures and may lose consciousness, so consuming carbohydrates may not be an option.

What stimulates glycogenolysis?

Friends and family members of people who are prone to severe hypoglycemia should learn how to use a glucagon[4] emergency kit. Injecting glucagon stimulates glycogenolysis[5] and raises blood glucose levels.

Want to learn more about hypoglycemia? Read “Understanding Hypoglycemia,”[6] “Take a Bite Out of Hypoglycemia: 10 Proven Strategies for Cutting Down on Low Blood Glucose,”[7] and “Hypoglycemia: What Your Inner Circle Needs to Know.”[8]

  1. glycogen:
  2. type 1 diabetes:
  3. hypoglycemia:
  4. glucagon:
  5. Injecting glucagon stimulates glycogenolysis:
  6. “Understanding Hypoglycemia,”:
  7. “Take a Bite Out of Hypoglycemia: 10 Proven Strategies for Cutting Down on Low Blood Glucose,”:
  8. “Hypoglycemia: What Your Inner Circle Needs to Know.”:

Source URL:

Disclaimer of Medical Advice: Statements and opinions expressed on this Web site are those of the authors and not necessarily those of the publishers or advertisers. The information, which comes from qualified medical writers, does not constitute medical advice or recommendation of any kind, and you should not rely on any information contained in such posts or comments to replace consultations with your qualified health care professionals to meet your individual needs.