Physical Activity May Reduce Neuropathy Risk in Type 1

In people with type 1 diabetes[1] for 50 years or longer, greater physical activity is linked to a lower risk of developing peripheral neuropathy[2] — nerve damage affecting the limbs, usually the legs or feet — according to a new study published in the Journal of Diabetes and its Complications[3].

Peripheral neuropathy often develops in people with diabetes as a result of long-term exposure to elevated blood glucose levels[4], which can lead to nerve damage. It can cause uncomfortable to painful symptoms, which may include numbness, tingling, or burning sensations. Treatment guidelines for peripheral neuropathy mainly focus on reducing pain[5], rather than addressing the underlying condition — but there is some evidence that certain behaviors can address some of the root causes of neuropathy, as well as reduce the risks associated with the condition. For example, addressing low vitamin D levels has been shown[6] to help reduce neuropathic pain, indicating that a lack of adequate vitamin D may be one culprit in reduced nerve function. Losing weight may also help[7] improve neuropathy symptoms, possibly in part due to the beneficial effects this has on metabolic health in general. And being more active by reducing sedentary time has been shown[8] to lower the risk of developing foot ulcers[9] — sores that don’t heal easily — in people with peripheral neuropathy.

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For the latest study, researchers looked at data from 75 participants in a study called the Canadian Study of Longevity in Type 1 Diabetes[11]. The average age of participants was 66, their average diabetes duration was 54 years, and their average A1C level[12] (a measure of long-term blood glucose control) was 7.3%. As part of the study, participants underwent a physical exam, had their medical history taken, and reported their physical activity during the previous 12 months. For this analysis, the researchers were interested in comparing weekly physical activity levels with measures of diabetic neuropathy — such as nerve conduction tests, which use electrical impulses to measure how well nerves transmit signals. Physical signs and reported symptoms were also used to assess peripheral neuropathy.

More physical activity linked to reduced rates of neuropathy

The average amount of weekly physical activity among participants was 156 minutes, and 65 participants (87%) had what’s known as distal symmetric polyneuropathy (DSPN) — neuropathy on both feet or legs. The researchers found that participants with DSPN had significantly lower levels of physical activity than those without the condition — an average of 141 minutes per week, compared with 258 minutes per week for those who didn’t have DSPN. Greater physical activity was also linked to better outcomes on specific physical and neurological measures, including cooling detection threshold (ability to feel a cold surface on the affected areas), peroneal and sural amplitude, and conduction velocity (measurement of nerve function). After adjusting for participants’ age and A1C level, the researchers found that for every additional 30 minutes of weekly physical activity, there was a predictable improvement in two measures of nerve function — a 0.09mv higher peroneal amplitude and a 0.048 ms lower peroneal F-wave latency.

“In longstanding [type 1 diabetes], [physical activity] time is associated with superior large nerve fiber function in the lower limbs and some better measures of small nerve fiber function,” the researchers concluded. These results, they wrote, may provide a justification for studying the effects of an exercise “prescription” on neuropathy-related outcomes in people with longstanding diabetes.

Want to learn more about neuropathy? Read “Coping With Painful Neuropathy,”[13] “Diabetic Peripheral Neuropathy,”[14] and “Controlling Neuropathic Pain.”[15]

Want to learn more about exercising with diabetes? Read “Add Movement to Your Life,”[16] “Picking the Right Activity to Meet Your Fitness Goals”[17] and “Seven Ways to Have Fun Exercising.”[18]

  1. type 1 diabetes:
  2. peripheral neuropathy:
  3. Journal of Diabetes and its Complications:
  4. blood glucose levels:
  5. mainly focus on reducing pain:
  6. addressing low vitamin D levels has been shown:
  7. Losing weight may also help:
  8. reducing sedentary time has been shown:
  9. foot ulcers:
  10. sign up for our free newsletters:
  11. Canadian Study of Longevity in Type 1 Diabetes:
  12. A1C level:
  13. “Coping With Painful Neuropathy,”:
  14. “Diabetic Peripheral Neuropathy,”:
  15. “Controlling Neuropathic Pain.”:
  16. “Add Movement to Your Life,”:
  17. “Picking the Right Activity to Meet Your Fitness Goals”:
  18. “Seven Ways to Have Fun Exercising.”:

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